Aquasolve hypromellose acetate succinate hpmcas gradea weight average molecular weight nominal viscosity mpas b l 114,700 2. Sample quantities of methocel products are available free of charge for your developmental work. You can obtain samples by calling one of the numbers listed on the back cover of this. Msds examples sds sheets msds authoring services inc. Material safety data sheet carboxymethyl cellulose, sodium. Affinisol hpmcas for spraydried dispersion sdd hpmcas to the solution to give a clear to slightly opaque final solution with 25 wt% api to 75 wt% affinisol hpmcas ratio. Weight loss, early deaths and severe diarrhea was observed only at the 25% level. Relying on the advanced and refined testing equipment, as well as the ambitious spirit to provide the best products in the worl hypromsllose.
Methocel e4m hypromellose 2910 usp sds preparation date 07032017 page 1 of 8. Our core businesses include film coatings, modified release. The solutions were spray dried on a bend minisd spray drying unit and the resulting samples. Pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. Hypromellose has a physicalchemical action and leads to, in an aqueous solution, a reduced surface tension as well as an increased level of viscosity. Examples safety data sheet sdsmsds here you can see examples of safety data sheets in some of the various languages we handle. Contact with the skin is not expected to cause prolonged or significant irritation. Generic safety data sheet sds cover sheet sample preparation kit ki3010 component description ch 2003 alkylation solution ch 2004 reduction stock solution so. Material safety data sheet carboxymethyl cellulose, sodium salt, average mw 90. Accelio present applied technology created and tested using. Add the sample solution to exactly 50ml of hypromellose water in a beaker. Being a part of the shinetsu group, we unite innovation and tradition. Stir the solution on a magnetic stirrerhot plate, portions of this monograph that are national usp text, and and begin heating at a rate of 25min. Msds authoring services specialize in msds writing, creation, development and authoring.
For a highquality, custom msds binder, look to binders, inc. Methocel e4m hypromellose 2910 usp encore scientific. Upper layer of the standard solution and the samples having a viscosity type of less than 600 mpa sample solution s. Affinisol hpmcas for spraydried dispersion sdd solving. Formerly known as material safety data sheets, phac now refers to them as pathogen safety data sheets or psdss. Handling and storage protect container from physical. Pdf bookmark sample page 1 of 4 pdf bookmark sample sample date. Our sturdy, wellmade professional binders, along with index tab dividers, are sure to keep all your information safe. Certificate of analysis coa specification sheet pdf. This information is to the best of our knowledge is considered accurate.
Safety data sheet section 1 identification of the substancemixture and of the companyundertaking. Material is dusty and may scratch the surface of the eye. Add the sample solution to exactly 50 ml of water in a beaker. Transfer a quantity of hypromellose 3 in the portion of hypromellose taken. Never give anything by mouth to an unconscious person. Methocel cellulose ethers include methylcellulose mc or hydroxypropyl methylcellulose hpmc polymers with solubilities ranging from watersoluble to organosoluble. Safety data sheet gasoline, unleaded sample please note. Gon iovisc hypromellose ophthalmic demulcent solution, 2. Hydroxypropylmethyl cellulose, hydroxypropylmethylcellulose 2910. The cellulose department has prepared safety data sheets sds for our major. Alert a doctor if you have ever had any unusual or allergic reaction to hypromellose.
A liquid is typically considered a nonconductive, static accumulator if its. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Stage 6 harmonization official december 1, 2016 hypromellose1 analysis. Effect of formulation conditions on hypromellose performance properties in films used for capsules and tablet coatings. Before films were prepared, dissolved gas was removed from the solution by placing the sample. Calculate the percentage of methoxy och sample solution. Aquasolve hpmcas for pharmaceutical applications is a cellulosic polymer with four substituents randomly substituted on the available hydroxyl groups with the following mass. The information in this msds is written in good faith, but no warranty is given, to what is expressed or implied. Transfer a quantity of hypromellose w u weight of hypromellose, calculated on the equivalent to 10g of solids, calculated on the dried dried basis, taken for the sample solution basis, to a tared, widemouth centrifuge bottle, and mg add hot water to obtain a total weight of the sample.
Visit the reach website for more information regarding dow and reach. Give the person a glass of water or milk to drink and get immediate medical attention. Recommend splash protection or chemical safety glasses contaminated equipment. The viscosity promoting properties of hypromellose prolong the retention time and improve adhesion of synthetic tears to the cornea and conjunctiva. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Review the material safety data sheet msds for this material prior to working with this chemical. Benecel methylcellulose and hypromellose hydroxypropyl methylcellulose or hpmc are. Similar results were observed when groups of 20 rats were fed a diet of 2, 10 and 25% for 30 days. Rather than being abused, hypromellose is included in oral formulations of ms contin, oxycontin, opana er, and others. Not expected to be harmful to internal organs if absorbed through the skin. Material safety data sheet bnz materials industrial. Material safety data sheet croscarmellose sodium page 3 of 5 section 8 exposure controls personal protection engineering controls.
We work hard to ensure that we are fully uptodate with regulations, and make sure to incorporate changes as soon as they occur, so that you do not risk having outofdate safety data sheets. Other companies are charging thousands of dollars to set up accounts and give you. Methocel k100m premium hydroxypropyl methylcellulose. In two dogs fed a diet containing 25 or 50 g hpmc daily for 30 days only the dog fed 50g experienced weight loss, diarrhea and anemia. Sample form letter for msds request their address city, state, zip code. Sigmaaldrich offers a number of hypromellose products. Do not use combustible materials, such as saw dust. Examples safety data sheet sds msds here you can see examples of safety data sheets in some of the various languages we handle. Hypromellose meets usp testing specifications sigmaaldrich. All spectrum chemical usp products are manufactured, packaged and.
566 12 899 868 1553 891 10 1164 612 751 638 48 67 232 1474 248 465 790 405 1532 1496 563 1568 1550 733 1062 925 1137 64 671 252 831 874 798 97 69 857 185